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Synthesis of 1-Amino-2-[3-13C]propanol Hydrochloride: Completion of Synthetic Methods for all of its 13C- and 15N-Isotopomers

[ Vol. 1 , Issue. 2 ]

Author(s):

K. Iida, Y. Nakajima and M. Kajiwara   Pages 120 - 121 ( 2 )

Abstract:


1-Amino-2-[3-13C]propanol hydrochloride (1) was synthesized by the coupling reaction of 2-phthalimidoacetyl chloride (2) with [13C]methylmagnesium iodide in the presence of copper iodide, followed by reduction with sodium borohydride and hydrolysis, in 64 % total yield from the 13C-source. All 13C- and 15N-isotopomers of 1-amino-2-propanol are now obtainable by using appropriate combinations of 13C-labeled sodium acetate, 13C- and/or 15N-labeled glycine, and potassium [15N]phthalimide.

Keywords:

13C-labeling synthesis, 1-amino-2-[3-13C]propanol, iodo[13C]methane, 13C, 15N-isotopomer, vitamin B12, biosynthetic intermediate

Affiliation:

Department of Medicinal Chemistry,Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.



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