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A Review of Accelerator-Produced Ga-68 with Solid Targets

[ Vol. 14 , Issue. 4 ]

Author(s):

Kaelyn V. Becker, Margarita Chernysheva, Todd E. Barnhart, Katherine Gagnon and Jonathan W. Engle*   Pages 315 - 324 ( 10 )

Abstract:


Gallium-68 is a positron-emitting nuclide that has recently achieved clinical acceptance as the diagnostic radionuclide in PET tracers used for theranostic studies of lutetium-177 labeled therapeutic drugs due to the ease of access provided by germanium-68/gallium-68 generators. An alternative method of production currently being explored uses accelerators to form gallium-68 directly. This review of gallium-68 production strategies discusses available accelerator targetry at a range of beam energies and intensities, the many radiochemical separation techniques available to isolate Ga-68 from irradiated targets, isotopically enriched target material recovery, and the implications of these techniques for downstream radiolabeling applications.

Keywords:

Radiochemical, PET, therapeutic molecule, gallium-68, radiochemistry, Lu-177 labeled.

Affiliation:

Departments of Medical Physics and Radiology, University of Wisconsin Madison. B1303 WIMR Cyclotron Laboratory, 1111 Highland Avenue, Madison WI 53705, Departments of Medical Physics and Radiology, University of Wisconsin Madison. B1303 WIMR Cyclotron Laboratory, 1111 Highland Avenue, Madison WI 53705, Departments of Medical Physics and Radiology, University of Wisconsin Madison. B1303 WIMR Cyclotron Laboratory, 1111 Highland Avenue, Madison WI 53705, Cyclotrons and TRACERcenter GE Healthcare Uppsala, Departments of Medical Physics and Radiology, University of Wisconsin Madison. B1303 WIMR Cyclotron Laboratory, 1111 Highland Avenue, Madison WI 53705



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