Marco Spadafora*, Laura Evangelista, Salvatore Fiordoro, Francesco Porcaro, Marilena Sicignano and Luigi Mansi Pages 1 - 6 ( 6 )
Purpose: The Italian Tailored Assessment of Lung Indeterminate Accidental Nodule (ITALIAN) trial is a trial drawn to determine the performance of 18F-FDG-PET/CT in patients with solitary pulmonary nodules (SPN) , stratified for different kind of risk. An additional end-point was to compare the diagnostic information and estimated dosimetry, provided by a segmental PET/CT (s-PET/CT) acquisition instead of a whole body PET/CT (wb-PET/CT), in order to evaluate if segmental thoracic PET/CT can be used in patients with SPN.
Methods: 18F-FDG PET/CT of 502 patients, stratified for pre-test cancer risk, were retrospectively analyzed. FDG uptake in SPN was assessed by a 4-point scoring (4PS) system and a semiquantitative analysis using the ratio between SUVmax in SPN and SUVmean in mediastinal blood pool (BP), and between SUVmax in SPN and SUVmean in liver (L). Histopathology and/or follow-up data were used as standard of reference. Data obtained on the thoracic part of wb-PET/CT, defined as s -PET/CT, were compared with those deriving from wb-PET/CT.
Results: SPN were malignant in 180 patients (36%) , benign in 175 (35%), and indeterminate in 147 (29%). The 355 patients diagnosed with a definitive SPN nature (malignant or benign) were considered for the analysis of PET performance. Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values, and accuracy were 85.6%, 85.7%, 86%, 85.2%, and 85.6% respectively. Sensitivity and PPV were higher in intermediate and high-risk patients.
18F-FDG uptake indicative of thoracic and extra-thoracic lesions was detectable in 13% and 3% of the patients. Compared to wb-PET/CT, s-PET/CT could save about 2/3 of 18F-FDG dose, radiation exposure or scan-time, without affecting the clinical impact of PET/CT.
Conclusion: In patients with SPN, the pre-test likelihood of malignancy stratification allows to better define PET clinical setting and its diagnostic power. In subjects with low-intermediate pre-test likelihood of malignancy, s-PET/CT might be planned in advance. The adoption of this segmental strategy could reduce radiation exposure, scan-time, and might allow individually targeted protocols.
PET/CT (s-PET/CT) acquisition, SUVmax in SPN, 18F-FDG, FDG uptake Thoracic lymph
Nuclear Medicine Unit, Ospedale del Mare, Nuclear Medicine Unit, Veneto Institute of Oncology IOV - IRCCS , Nuclear Medicine Unit, Ospedale del Mare, Nuclear Medicine Unit, Ospedale del Mare, Nuclear Medicine Unit, Ospedale del Mare, Section Health and Development, Interuniversity Research Center for Sustainability (CIRPS)