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Potential of Radiolabeled PSMA PET/CT or PET/MRI Diagnostic Procedures in Gliomas/Glioblastomas

Author(s):

Francesco Bertagna*, Domenico Albano, Elisabetta Cerudelli, Maria Gazzilli, Raffaele Giubbini and Giorgio Treglia   Pages 1 - 5 ( 5 )

Abstract:


Background: Radiolabelled prostate specific membrane antigen PSMA-based PET/CT or PET/MRI is a whole-body imaging technique currently performed for the detection of prostate cancer lesions. PSMA has been also demonstrated to be expressed by the neovasculature of many other solid tumors.

Objective: The aim of this review is to evaluate the possible diagnostic role of radiolabelled PSMA PET/CT or PET/MRI in patients with gliomas and glioblastomas, by summarizing the available literature data.

Methods: A comprehensive literature search of the PubMed/MEDLINE, Scopus, Embase and Cochrane library databases was conducted to find relevant published articles about the diagnostic performance of radiolabeled PSMA binding agents in PET/CT or PET/MRI imaging of patients with suspected gliomas or glioblastomas.

Results: Seven case reports or case series and 3 studies enrolling more than 10 patients showed that gliomas and glioblastoma are PSMA-avid tumors.

Conclusion: Radiolabelled PSMA imaging seems to be useful in analyzing glioma/glioblastoma. Further studies enrolling a wider population are needed to clarify the real clinical and diagnostic role of radiolabelled PSMA in this setting and its possible position in the diagnostic flow-chart.

Keywords:

PSMA, prostate specific membrane antibodies, glioma, glioblastoma, PET, positron emission tomography

Affiliation:

Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, Brescia, Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, Brescia, Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, Brescia, Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, Brescia, Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, Brescia, Department of Nuclear Medicine and PET/CT Center, Imaging Institute of Southern Switzerland, Bellinzona and Lugano



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