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Experiences with 99mTc-HMPAO in a Diagnostic Pathway for Violent Patients with Schizophrenic Spectrum Disorders

[ Vol. 10 , Issue. 2 ]

Author(s):

Morten Jacobsen*, Arvid Jensen, Guttorm Breivik Storvestre, Tone Marie Bergstrom, Diyar Nori Mohamad Rashi, Bjorn Nielssen , Pal Wiktor and Knut-Erik Hymer   Pages 115 - 122 ( 8 )

Abstract:


Background and Objective: In a security ward we assessed the diagnostic contribution of single photon scintigraphy [SPECT] in our diagnostic pathway for patients with serious mental disease and a history of violence.

Methods: Twenty patients were examined between 2012 and 2015 and the findings compared to those in nine patients with the same diagnosis, but no history of violence.

Results: All violent patients had areas with reduced accumulation of 99mTc-HMPAO frontally and in the temporal lobe, in the non-violent group only two patients demonstrated these findings.

Conclusion: Traditionally, low accumulation of the tracer in SPECT is related to reduced perfusion of brain tissue. We discuss our findings in the light of other possible pathophysiological mechanisms.

Keywords:

SPECT, Schizophrenia spectrum disorder, brain perfusion, violence, forensic psychiatry.

Affiliation:

University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Postbox 1171 Blindern 0318, Oslo, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum, Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum

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