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Gallium-68 in Medical Imaging

[ Vol. 9 , Issue. 3 ]

Author(s):

Lucia Martiniova, Louis De Palatis, Elba Etchebehere and Gregory Ravizzini   Pages 187 - 207 ( 21 )

Abstract:


Over the past several years, Positron Emission Tomography (PET) imaging agents labeled with 68Gallium (68Ga) have undergone a significant increase in clinical utilization. 68Ga is conveniently produced from a germanium-68/gallium-68 (68Ge/68Ga) generator. Because of the compact size and ease of use of the generator, 68Ga labeled compounds may be more cost-effective than PET radioisotopes that are cyclotron-produced. The convenient half-life of 68Ga (T1/2=68 min) provides sufficient radioactivity for various PET imaging applications, while delivering acceptable radiation doses to patients. This chapter summarizes the emerging clinical utilization of 68Ga-based radiotracers in medical imaging.

Keywords:

68Gallium, generator, neuroendocrine tumors, positron emission tomography, somatostatin receptor scintigraphy, PSMA.

Affiliation:

University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit Number: 1483, Houston, TX 7703, USA.

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